Microbiology 214:
Mechanisms of Bacterial Pathogenesis and Host Immune Response

Fall Semester 2017
Tuesdays and Thursdays Aug. 31-Nov. 30
10:00am to 12:00 noon

NRB 1031


Instructors: Marcia Goldberg (course director), Min Dong, Darren Higgins, Jon Kagan, Michael Starnbach, Suzanne Walker
Curriculum Fellow: Deepali Ravel (dravel@fas.harvard.edu)

Syllabus

 
Date
Instructor
Topic
Required
Background
     
1
8/31/17
Goldberg Overview of host pathogen interactions
1, 2
3, 4
2
9/5/17
Goldberg Mechanisms of entry using type 3 secretion
3, 4
3
9/7/17
Goldberg Type 3 secretion disruption of host signaling pathways
1, 2
3, 4
4
9/12/17
Walker Mechanisms of antibiotics and approaches to antibiotic discovery
1, 2
3, 4, 5, Figs
5
9/14/17
Walker Antibiotics II
1, 2
6
9/19/17
Walker Alternatives to broad spectrum antibiotic monotherapy for treating bacterial infections
1,2,3,4
5, 6
9/21/17
NO CLASS
7
9/26/17
Kagan Cellular trafficking and type 3 secretion
1, 2
8
9/28/17
Starnbach NFKB signaling
1,2,3,4
9
10/3/17
Starnbach Alteration of host ubiquitination
1,2,3
10
10/5/17
Starnbach Autophagy
1,2,3
11
10/10/17
Starnbach Overview of immune response to pathogens (innate and adaptive)
12
10/12/17
Starnbach Regulation of chronic infection
1, 2
13
10/17/17
Starnbach Bacterial manipulation of adaptive immunity
1, 2
14
10/19/17
Kagan Mechanisms of living within a vacuole
1,2,3
15
10/24/17
Kagan Toll-like receptors
1, 2
16
10/26/17
Kagan Inflammasome activation
1,2,3,4
17
10/31/17
Kagan Disease tolerance
1,2,3
18
11/2/17
Kagan Manipulation of MAP kinase pathways
1, 2
19
11/7/17
Ravel Bacterial killing via type 6 secretion systems
1,2,3,4
5, 6
20
11/9/17
Dong Other bacterial toxins
1, 2
3, 4
21
11/14/17
Higgins Mechanisms of entry into cells (non-type 3 secretion mediated)
1, 2
22
11/16/17
Higgins Actin-based motility
1, 2
23
11/21/17
Higgins Bacteria and apoptosis
11/23/17
NO CLASS
24
11/28/17
Higgins Biofilms
1, 2
25
11/30/17
Higgins Vaccine development and adjuvants
1, 2

Course Website: http://micro.med.harvard.edu/pages/micro214.html

Readings will be posted on the course website. You are expected to have thoroughly read the assigned papers before arriving at class.

Attendance Policy: If you need to miss class, let the scheduled lecturer (see course schedule below) and curriculum fellow know in advance. Absences of which we are not informed in advance (barring emergencies) will result in a reduced participation grade. If you miss more than one class, you will be asked to write a 1-page (single-space) summary of the assigned papers you missed.